Through the regularization of stimulation-induced neural output patterns, our DBS systems suppress local neuronal firing while simultaneously activating both orthodromic and antidromic axonal conduction. By exerting complex excitatory and inhibitory effects, our DBS systems modulate the basal ganglia–thalamocortical network and normalize the pathological firing patterns associated with Parkinson’s disease, thereby improving both motor and non-motor symptoms in patients with Parkinson’s disease. The following diagram illustrates the working mechanism of our DBS systems.
2022-02-13
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